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    1. Solutions of Blood Products Process Filtration

      Blood Products -cbt.jpg

      Immunoglobulins include static C, muscle C and specific immunoglobulins. Static C is a complete, unmodified, natural IgG antibody with a purity of 98%, which is intended for intravenous infusion and is similar to that of human immune globulin. Globulin (myocardial infusion) has a fast-acting, compared to coagulation factors: human fibrinogen, human coagulation factor VIII (factor VIII). ) and the human prothrombin complex (PCC). 


      Blood makes up about 8% of body weight (v/w), plasma makes up 50% of whole blood (v/w), and plasma proteins make up about 6- 7% and 92% are water. There are more than 200 known plasma proteins, of which more than 100 have been purified, more than 70 are well studied, and more than 70 have been manufactured. There are more than 20 types of products and about 10 types of finished products in China. Their main products include the following.


      50%-60% of plasma protein and 80% of osmolality comes from albumin, which has the ability to increase circulating blood volume and maintain the role of osmolarity of the organism. Albumin is the only blood product allowed to be imported into China, with importers supplying between 50% and 60% of the albumin.


      Immunoglobulins include static C, muscle C and specific immunoglobulins. Static C is a complete, unmodified, natural IgG antibody with a purity of 98%, which is intended for intravenous infusion and is similar to that of human immune globulin. Globulin (myocardial infusion) has a fast-acting, compared to coagulation factors: human fibrinogen, human coagulation factor VIII (factor VIII). ) and the human prothrombin complex (PCC).


      The main production method of blood products is the low-temperature ethanol method, which uses mixed plasma as the raw material to gradually reduce the acidity (from pH 7.0 to pH 4.0). Increasing the ethanol concentration (from 0 to 40%) and simultaneously decreasing the temperature (from 2°C to -2°C), various proteins in different conditions the following are precipitated from the solution as components (crude products) in steps and separated by centrifugation or filtration.



      IVIG 

      IVIG Process.jpg



      ① Ethanol Filtration

      Particle Control

      Greclary CHV -Glass Fiber

      Excesal CHE -PP

      Excesal CHC -PP
      Excesal CHT -PP

      Safetect PME -PES


      Sterile Filtration

      Purcise SLE -Double Layer PES

      Corevital SAF -Double Layer PES

      Corevital SMD -PVDF



      ② Vent

      Safesure AFM -Hydrophobic PTFE

      Corevital APB -Hydrophobic PVDF



      Pressure Filtration

      Roheap CSD



      ④ Clarification Filtration

      Roheap CSD


      ⑤ Column / TFF Protection

      Bioburden Reduction/Pre-filtraiton

      Safetect PME -PES

      Purcise PLE -Double Layer PES

      Purcise PAF -PES

      Corevital PMD?-PVDF


      Sterilization Filtration

      Purcise SLE -Double Layer PES

      Corevital SAF -Double Layer PES

      Corevital SMD -PVDF



      ⑥ Concentration and Purification

      Consieve?UET TFF
       ( Cassettes /Stainless Holder /System?
      )




      ⑦ Buffer Filtration

      Bioburden Reduction/Pre-filtraiton

      Safetect PME -PES

      Purcise PLE -Double Layer PES

      Purcise PAF -PES

      Corevital PMD?-PVDF




      ⑧ Sterile Filtration

      Purcise SLE -Double Layer PES

      Corevital SAF -Double Layer PES

      Corevital SMD -PVDF



      ⑨ 0.1μm filtration

      Purcise MLE -Double Layer PES



      ⑩ nanofiltration

      Being Developed







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